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Alzheimer's disease occurs when brain cells start dying. The size of the brain decreases to a great extent. There are very few connections and nerve cells in the brain tissue. A postmortem/autopsy may only show small inclusions inside the neural tissues. This is called tangles and plaques. Plaques are formed due to the formation of a substance called beta-amyloid (amyloid plaque). The tangles of brain neurons are formed due to the dissolution of a protein called tau. According to the researchers, Alzheimer's disease goes way beyond protein abnormalities. Alzheimer's disease makes it difficult to recognize faces and objects. The most prominent signs include problem solving, decisions, and reasoning. A form of dementia called vascular dementia is caused by a traumatic event such as stroke, the most common type of dementia after Alzheimer's disease.
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